5. Channels, Transporters, and Kidney Diseases
نویسندگان
چکیده
منابع مشابه
Organellar channels and transporters.
Decades of intensive research have led to the discovery of most plasma membrane ion channels and transporters and the characterization of their physiological functions. In contrast, although over 80% of transport processes occur inside the cells, the ion flux mechanisms across intracellular membranes (the endoplasmic reticulum, Golgi apparatus, endosomes, lysosomes, mitochondria, chloroplasts, ...
متن کاملCLC chloride channels and transporters.
CLC proteins are found in cells from prokaryotes to mammals and perform functions in plasma membranes and intracellular vesicles. Several genetic human diseases and mouse models underscore their broad physiological functions in mammals. These functions range from the control of excitability to transepithelial transport, endocytotic trafficking and acidification of synaptic vesicles. The recent ...
متن کاملTransporters as channels.
This review investigates some key aspects of transport mechanisms and recent advances in our understanding of this ubiquitous cellular process. The prevailing model of cotransport is the alternating access model, which suggests that large conformational changes in the transporter protein accompany cotransport. This model rests on decades of research and has received substantial support because ...
متن کاملFunctional significance of channels and transporters expressed in the inner ear and kidney.
A number of ion channels and transporters are expressed in both the inner ear and kidney. In the inner ear, K(+) cycling and endolymphatic K(+), Na(+), Ca(2+), and pH homeostasis are critical for normal organ function. Ion channels and transporters involved in K(+) cycling include K(+) channels, Na(+)-2Cl(-)-K(+) cotransporter, Na(+)/K(+)-ATPase, Cl(-) channels, connexins, and K(+)/Cl(-) cotran...
متن کاملInvited Review Functional significance of channels and transporters expressed in the inner ear and kidney
Florian Lang, Volker Vallon, Marlies Knipper, and Philine Wangemann Department of Physiology, Eberhard-Karls-University of Tübingen, Tubingen, Germany; Departments of Medicine and Pharmacology, University of California, and Veterans Affairs San Diego Healthcare System, San Diego, California; Department of Otorhinolaryngology, Tübingen Hearing Research Centre, Molecular Neurobiology, Tübingen, G...
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ژورنال
عنوان ژورنال: Nihon Naika Gakkai Zasshi
سال: 2014
ISSN: 0021-5384,1883-2083
DOI: 10.2169/naika.103.705